F-Series dialyzers - Fresenius Medical Care

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Key features

Fresenius Polysulfone^® — A synonym for biocompatibility

Adverse interactions between blood and material arising during the dialysis treatment have been related to a variety of clinical symptoms
It has become increasingly evident that not all dialysis membranes are the same with respect to their ability to activate blood cell components¹
Ever since its introduction, Fresenius Polysulfone^® has been recognized for its biocompatibility and was an established benchmark for all membrane improvements and developments ^2,3,4,5

Safety during each and every treatment

All Fresenius Medical Care dialyzers provide a high degree of safety during each and every treatment
The high endotoxin retention capabilities of the Fresenius Polysulfone^® are attributed to the chemical composition and structure of the membrane

Enhanced design for maximum efficiency

The special undulating structure of the hollow fibers delivers an excellent performance profile
Spacing between the wavy fiber structures keeps the individual fibers apart, preventing dialyzate channeling and facilitating a uniform flow of dialyzate within the fiber bundle
The consistent dialyzate flow around each fiber ensures every single performs at maximum efficiency, resulting in enhanced solute transport

INLINE steam sterilization – how it works

Both the blood and the dialysate compartment of the dialyzers are rinsed continuously with steam at a temperature at or above 121°C for a minimum of 15 minutes. Rinsing with hot steam and without chemicals results in extremely low levels of residuals in the dialyzer
The dialyzer is rinsed with sterile water
Every dialyzer is tested for fiber integrity using a bubble-point test
The dialyzers are dried with warm, sterile air
Finally, after drying the blood inlet and outlet ports are closed

Performance data

Low Flux Dialysers – High Performance Steam (HPS)

Low Flux Dialysers – High Performance Steam (HPS)	F4 HPS	F5 HPS	F6 HPS	F7 HPS	F8 HPS	F10 HPS
Ultrafiltration coefficient (ml/h x mmHg)	8	10	13	16	18	21
Clearance: QB: (200ml/min)
Urea	170	179	186	188
Creatinine	149	162	173	175
Phosphate	123	139	148	155
Vitamin B12	75	84	92	102
Clearance: QB: (300ml/min)
Urea		227	243	247	252	259
Creatinine		196	215	220	224	230
Phosphate		162	175	186	193	208
Vitamin B12		91	100	113	118	131
Clearance: QB: (400ml/min)
Urea					290	300
Creatinine					251	259
Phosphate					212	231
Vitamin B12					124	139
The in vitro performance data were obtained with QD = 500ml/min: QF = 0ml/min; T=37°C (ISO8637) The ultrafiltration coefficients were maintained using human blood, Hct = 32%, protein content 6%
Effective surface area (m²)	0.8	1.0	1.3	1.6	1.8	2.2
Blood priming volume (ml)	51	63	78	96	113	132
Membrane material	Fresenius Polysulfone^®
Housing material	Polycarbonate
Potting compound	Polyurethane
Sterilization method	Inline Steam
Form of treatment	HD
Art. No.	5007041	5007051	5007061	5007071	5007081	5007201

High Flux Dialysers

High Flux Dialysers	F40S	F50S	F60S	F70S	HF80S	HdF100S
Ultrafiltration coefficient (ml/h x mmHg)	20	30	40	50	55	60
Clearance: QB: (200ml/min)
Urea	165	178	185	190
Creatinine	140	160	172	177
Phosphate	138	158	170	174
Vitamin B12	80	100	118	127
Inulin	54	75	88	98
Clearance: QB: (300ml/min)
Urea	200	225	242	245	248	271
Creatinine	165	195	215	220	225	252
Phosphate	158	190	210	216	220	240
Vitamin B12	86	112	134	145	155	190
Inulin	58	83	97	109	120	145
Clearance: QB: (400ml/min)
Urea	222	252	276	281	285	285
Creatinine	178	215	238	254	250	272
Phosphate	170	206	230	241	245	260
Vitamin B12	90	118	144	159	170	215
Inulin	60	87	103	118	126	170
The in vitro performance data were obtained with QD = 500ml/min: QF = 0ml/min; T=37°C (ISO8637) The ultrafiltration coefficients were maintained using human blood, Hct = 32%, protein content 6%
Effective surface area (m²)	0.7	1.0	1.3	1.6	1.8	2.3
Blood priming volume (ml)	42	63	82	98	110	132
Membrane material	Fresenius Polysulfone^®
Housing material	Polycarbonate
Potting compound	Polyurethane
Sterilization method	Inline Steam
Art. No.	5007141	5008151	5007161	5007171	5007181	5007191

Attention

F-Series

Not all polysulfones are like Fresenius Polysulfone^®

Key features