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Do it for your patients                              

See what our patients, Joanna from Singapore and Mr. Tsai from Taiwan, have to say about their experience with HighVolumeHDF therapy.

"For (taking) HighVolumeHDF, I feel much stronger….
Having my grandson is a great joy to me and that’s a motivation for me also. I have to carry on, I have to make myself better, and I can play with him more."

- Joanna

"On the doctor’s suggestion, I adopted the new therapy (HighVolumeHDF). I’ve undergone dialysis for almost 30 years. Physically I am well able for my job, and have never been hospitalized for my kidney problem."

- Mr Tsai

A history of commitment to HDF

From hemodiafiltration to HighVolumeHDF®

HDF is a renal replacement technique combining two principles – diffusion and convection. The convective process is based on the ultrafiltration of large amounts of plasma water across the membrane. This allows for the effective removal of larger solutes due to convection in addition to the diffusive transport of small molecules.

To maintain the fluid balance it is necessary to replace the additional ultrafiltration volume, ideally after the dialyzer, the so-called post-dilution HDF.

Volume matters in hemodiafiltration


Therapy advantages

Reduced mortality risk with HighVolumeHDF®

HighVolumeHDF® — most advanced and still cost-efficient

Best use of resources with the CorDiax product line

HighVolumeHDF® – lower overall treatment costs


The Catalonian high-volume HDF study8

Improved Survival

Compared with patients maintained on conventional high-flux hemodialysis, those randomized to high-efficiency postdilution online hemodiafiltration had a significantly lower all-cause mortality.

Better patients‘ well-being

Reduced treatment costs

Study details8

Study aim:
To compare the impact of online hemodiafiltration over hemodialysis on patient survival.

Study design:
Multi-center, prospective randomized controlled trial promoted by the Catalonian Society of Nephrology.

Study endpoints:
The primary outcome variable was all-cause mortality, and secondary outcomes included cardiovascular mortality, all-cause hospitalization, treatment tolerance and laboratory data.

906 chronic hemodialysis patients were assigned either to continue hemodialysis (n=450) or to be switched to high-efficiency postdilution online hemodiafiltration (n=456).  

Get the study details


HighVolumeHDF® is Fresenius Medical Care

5008 and 5008S: HighVolumeHDF® as standard

FX CorDiax Hemodiafilters: Superior by design

Online Purification Cascade (OPC): Intelligent water quality management

Related content

1 Krick G, Ronco C (eds), Contributions to Nephrology (2011); 175: 93-109.

2 Canaud B., Contributions to Nephrology (2007); 158: 216-224.

3 Penne L. et al., Clinical Journal of the American Society of Nephrology (2010); 5: 80-86.

4 Davenport A., Nephrology Dialysis Transplantationt (2010); 25: 897-901.

5 Pedrini L. et al., Nephrology Dialysis Transplantation (2011); 26: 2617-2624.

6 Locatelli F. et al., Journal of the American Society of Nephrology (2010); 21: 1798-1807.

7 Bonforte G. et al., Blood Purification (2002); 20: 357-363.

8 Maduell F. et al., Journal of the American Society of Nephrology (2013); 24: 487-497.

9 Ok E., et al., Nephrology Dialysis Transplantation (2013); 28: 192-202.

10 Pedrini, L. et al., Nephrology Dialysis Transplantation  (2011); 26: 2617-2624.

11 Grooteman M.P. et al., Journal of the American Society of Nephrolog (2012); 23(6): 1087-96.

12 Canaud B. et al., Kidney International (2006); 69(11): 2087-93

13 Mostovaya I.M. et al., Seminars in Dialysis (2014); 27(2): 119-127.

14 Peters S.A.E. et al., Nephrology Dialysis Transplantation (2016); 31: 978-984.

15 Basile C. et al., Journal of Nephrology (2017); 30(2): 181-186.