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HighVolumeHDF® - Fresenius Medical Care

HighVolumeHDF® is Fresenius Medical Care

  • Reduced mortality risk
  • Best use of resources
  • Lower overall treatment costs 


Therapy advantages

Reduced mortality risk with HighVolumeHDF®

HighVolumeHDF® — most advanced and still cost-efficient

Best use of resources with the CorDiax product line

HighVolumeHDF® – lower overall treatment costs

From promise to proof

Our commitment to achieve the best possible results for every dialysis patient has fuelled our passion for hemodiafiltration (HDF). This passion rests on the firm belief that HDF is the best therapy for every patient.

Our conviction in HDF is now widely shared across the scientific community and backed by evidence. In recent years several publications have already confirmed the benefits of HDF8,9,11-15. The Catalonian high-volume HDF study8 provides accumulating evidence for the benefits of this therapy. Convincing scientific evidence for significantly improved patient outcomes combined with the simple and reliable use of the 5008 CorDiax are compelling reasons to switch to HighVolumeHDF® — now.

That’s why for more than 30 years Fresenius Medical Care has been developing products for Cardioprotective Hemodialysis, leading to the CorDiax product line — which perfectly supports the application of HighVolumeHDF® therapy.

A history of commitment to HDF

From hemodiafiltration to HighVolumeHDF®

HDF is a renal replacement technique combining two principles – diffusion and convection. The convective process is based on the ultrafiltration of large amounts of plasma water across the membrane. This allows for the effective removal of larger solutes due to convection in addition to the diffusive transport of small molecules.

To maintain the fluid balance it is necessary to replace the additional ultrafiltration volume, ideally after the dialyzer, the so-called post-dilution HDF.

Volume matters in hemodiafiltration


The Catalonian high-volume HDF study8

Improved Survival

Better patients‘ well-being

Reduced treatment costs

Study details8


HighVolumeHDF® is Fresenius Medical Care

5008 and 5008S: HighVolumeHDF® as standard

FX CorDiax Hemodiafilters: Superior by design

Online Purification Cascade (OPC): Intelligent water quality management

Related content

1 Krick G, Ronco C (eds), Contributions to Nephrology (2011); 175: 93-109.

2 Canaud B., Contributions to Nephrology (2007); 158: 216-224.

3 Penne L. et al., Clinical Journal of the American Society of Nephrology (2010); 5: 80-86.

4 Davenport A., Nephrology Dialysis Transplantationt (2010); 25: 897-901.

5 Pedrini L. et al., Nephrology Dialysis Transplantation (2011); 26: 2617-2624.

6 Locatelli F. et al., Journal of the American Society of Nephrology (2010); 21: 1798-1807.

7 Bonforte G. et al., Blood Purification (2002); 20: 357-363.

8 Maduell F. et al., Journal of the American Society of Nephrology (2013); 24: 487-497.

9 Ok E., et al., Nephrology Dialysis Transplantation (2013); 28: 192-202.

10 Pedrini, L. et al., Nephrology Dialysis Transplantation  (2011); 26: 2617-2624.

11 Grooteman M.P. et al., Journal of the American Society of Nephrolog (2012); 23(6): 1087-96.

12 Canaud B. et al., Kidney International (2006); 69(11): 2087-93

13 Mostovaya I.M. et al., Seminars in Dialysis (2014); 27(2): 119-127.

14 Peters S.A.E. et al., Nephrology Dialysis Transplantation (2016); 31: 978-984.

15 Basile C. et al., Journal of Nephrology (2017); 30(2): 181-186.