HDF is a renal replacement technique combining two principles – diffusion and convection. The convective process is based on the ultrafiltration of large amounts of plasma water across the membrane. This allows for the effective removal of larger solutes due to convection in addition to the diffusive transport of small molecules.
To maintain the fluid balance it is necessary to replace the additional ultrafiltration volume, ideally after the dialyzer, the so-called post-dilution HDF.
1 Krick G, Ronco C (eds), Contributions to Nephrology (2011); 175: 93-109.
2 Canaud B., Contributions to Nephrology (2007); 158: 216-224.
3 Penne L. et al., Clinical Journal of the American Society of Nephrology (2010); 5: 80-86.
4 Davenport A., Nephrology Dialysis Transplantationt (2010); 25: 897-901.
5 Pedrini L. et al., Nephrology Dialysis Transplantation (2011); 26: 2617-2624.
6 Locatelli F. et al., Journal of the American Society of Nephrology (2010); 21: 1798-1807.
7 Bonforte G. et al., Blood Purification (2002); 20: 357-363.
8 Maduell F. et al., Journal of the American Society of Nephrology (2013); 24: 487-497.
9 Ok E., et al., Nephrology Dialysis Transplantation (2013); 28: 192-202.
10 Pedrini, L. et al., Nephrology Dialysis Transplantation (2011); 26: 2617-2624.
11 Grooteman M.P. et al., Journal of the American Society of Nephrolog (2012); 23(6): 1087-96.
12 Canaud B. et al., Kidney International (2006); 69(11): 2087-93
13 Mostovaya I.M. et al., Seminars in Dialysis (2014); 27(2): 119-127.
14 Peters S.A.E. et al., Nephrology Dialysis Transplantation (2016); 31: 978-984.
15 Basile C. et al., Journal of Nephrology (2017); 30(2): 181-186.