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FX Dialyzers — Blue makes a difference

Why FX Dialyzers make a difference

FX Dialyzers have been used in more than 500 million treatments worldwide. As the world’s leading provider of dialysis products, Fresenius Medical Care aims to make a difference — for patients and healthcare professionals.

Continuous innovation combined with our commitment to the highest level of quality standards, ensure that our FX Dialyzers portfolio is built to address the individual needs of patients.

Why FX Dialyzers make a difference

FX portfolio

All FX Dialyzers have the capacity to remove a broad range of uremic toxins, effectively retain endotoxins, and provide intrinsic biocompatibility.1

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A smooth treatment is the difference that allows us to focus more on the patient.

FX properties that make a difference

Several state-of-the-art technologies have been combined to create the distinctive functional properties of the FX Dialyzers. Together they make a difference in terms of beneficial patient outcomes, smooth handling and cost savings potential.

FX properties that make a difference
  • 1. Lateral blood inlet port
  • 2. System compatibility and more
  • 3. Sophisticated fiber architecture
  • 4. Optimized header design
  • 5. INLINE steam sterilization
  • 6. Sustainable product design

Smooth handling

The blue header with its laterally placed blood inlet port is designed to reduce the risk of kinked bloodlines, aiming at smooth handling and allowing healthcare professionals to focus on what really matters — the best care for patients.

Smooth handling

Simplified workflows

Improved clearances

Fresenius Medical Care’s Nano Controlled Spinning (NCS™) technology creates fibers with a highly defined membrane architecture. Precise nanoscale modulation of pore size, structure and distribution favors minimal resistance to solute transfer across the membrane and contributes to improved clearances compared to macro-design membranes.10,11

Additionally, the microwave fiber structure enables the homogenous distribution of dialysis fluid, supported by the inner housing’s pinnacle design of the FX Dialyzers. It prevents the channelling of the dialysis fluid and ensures that each fiber within the bundle is perfectly surrounded by the dialysis fluid.11,12,13

Improved clearances

Enhanced performance

The optimized header design of the FX Dialyzers ensures a homogenous blood flow path. Its geometry allows a spiral distribution of blood in the dialyzer header, preventing low velocity stagnation zones and resulting in an enhanced performance.11

Enhanced performance

Setting the standard

Each FX Dialyzer is individually sterilized by the unique INLINE steam sterilization method. Both the blood and the dialysate compartments of the dialyzer are rinsed continuously with steam at a minimum temperature of 121° C, followed by sterile water and sterile air.

Rinsing with hot steam assures a gentle sterilization — without the need for chemicals or irradiation, which may lead to increased cytotoxic14 and carcinogenic residuals.15,16

Optimal use of resources

The INLINE steam sterilization process allows for the efficient use of resources during preparation as well as a reduction of costs, since only 500 mL rinsing volume is required. The process

  • includes a 100% fiber integrity test, aimed at minimizing the risk of blood leakages due to fiber ruptures
  • ensures that all FX Dialyzers are already pre-rinsed and ready to use upon arrival, resulting in short rinsing time and low rinsing volumes.

Best choice for high biocompatibility

Cytotoxicity is minimal after steam sterilization, whereas it increases with gamma irradiation.14 Studies have shown that with steam sterilized dialyzer membranes, less oxidative stress is induced to the patient’s blood compared to gamma sterilization.17,18,19

Performance characteristics remain intact

Changes of the material properties can be observed after sterilization with gamma irradiation, while the material remains intact in this respect when using steam sterilization.20

Increased losses of albumin during dialysis sessions have been observed with gamma sterilized dialyzers which were stored for a longer time.14,21

Setting the standard

Adding value across the entire life cycle


The difference is feeling confident throughout the entire treatment.

FX blue art project

Dialyzers are life-saving pieces of medical and technological art. The advanced design of the FX Dialyzers adds a dimension that reflects the thought, care and quality that went into its construction. As the most prominent visible characteristic, the color blue of the FX Dialyzer caps became the inspiration point for our unique blue art project. We asked artists to interpret the benefits of the FX Dialyzers in their own way — be it figurative or abstract, poetic or surreal, two- or three-dimensional — with stunning results.

Each artist granted another level of meaning, a unique interpretation or a new perspective to apply to the distinctive functional properties of the FX Dialyzers. Warm and sensitive, intellectual and meaningful approaches came to life.




Reliability and experience make a difference when seeking the best solutions

1 Wagner S. et al., Nephrology Dialysis Transplantation (2017); 32 (3): iii615.

2 Bock A. et al., J Am Soc Nephrol (2013); 24: SA-PO404.

3 Maduell F. et al., Blood Purif. (2014); 37(2): 125-130.

4 Lim P. S. et al., Artif Organs (2017); Nov 27. doi: 10.1111/aor.13011.

5 Schindler R. et al., Clin. Nephrology (2003); 59: 447–454.

6 Weber V. et al., Artif Organs (2004); 28(2): 210-217.

7 Chazot C. et al., Nephron (2015); 129: 269-275.

8 Tsai I.J. et al., Pediatr Nephrol (2014); 29: 111–116.

9 Data from Fresenius Medical Care Deutschland GmbH: Comparison clearance values F8 HPS (effective surface area 1.8 m2) versus FX 8 (effective surface area 1.4 m2).

10 Ronco C., Nissenson A. R., Blood Purif (2001); 19: 347-352.

11 Ronco C. et al., Kidney International (2002); 61 (80): 126-142.

12 Külz M. et al., Nephrol Dial Transplant (2002); 17: 1475-1479.

13 Mandolfo S. et al., The International Journal of Artificial Organs (2003); 26 (2): 113-120.

14 Allard B. et al., Le Pharmacien Hospitalier et Clinicien (2013); 48 (4): 15-21.

15 Shintani H., Biomedical instrumentation & technology (1995); 29 (6): 513–519.

16 Hirata N. et al., Radiation Physics and Chemistry (1995); 46 (3): 377–381.

17 Golli-Bennour E. E. et al., International urology and nephrology (2011); 43 (2): 483–490.

18 Azzabi A. et al., Néphrologie & Thérapeutique (2014); 10 (5): 318.

19 Golli-Bennour E.E et al., World J Nephrol Urol (2017); 6 (1-2): 14-17.

20 da Silva Aquino K. A., INtechOpen (2012); (27.04.2018).

21 Dawids S., Handlos V. N., Developments in hematology and immunology (1989); 347–368.

22 Unpublished data from Fresenius Medical Care Deutschland GmbH: Internal calculation based on weight measurements before treatment of FX Dialysers versus F-series dialysers.

23 Unpublished data from Fresenius Medical Care Deutschland GmbH: Internal calculation based on weight measurements of FME FX classix 80 versus FME HF 80S. The typical number of treatments in most clinics is approximately 10,000 per year; this results in about 1,600 kg less waste being produced annually with FX classix 80 when used on FME 5008 CorDiax machine.

24 EC-JRC-IES (2011): ILCD handbook – Recommendations for LCIA in the European context. Source: (all 15 environmental impact categories with recommendation in table 1 of this ILCD handbook have been evaluated).

25 Unpublished data from Fresenius Medical Care Deutschland GmbH internal study (2018): Comparative life cycle assessment of selected FME dialysers. Eco-performance is always calculated versus baseline product (FME HF 80S); long distance scenario illustrated.