Country websites:


The medical device and therapy related information on this website is aimed exclusively at healthcare professionals.

Not all products are cleared or available for sale in all Asia Pacific countries.

By clicking on the button "Accepted and Confirmed" you assure that you have taken note of this information and that you are a healthcare professional.



A perfect fit for every team

  • CRRT with integrated Ci-Ca® anticoagulation 
  • Allows therapy diversity with Therapeutic Plasma Exchange and sepsis therapy
  • Convenient handling, easing daily routines

Key features | Ci-Ca Therapeutic Plasma Exchange | Convenient handling

Key features at a glance

multiFiltratePRO Ci-Ca

Integrated Ci-Ca® citrate anticoagulation

Statement on the Ci-Ca® protocol:

[It] enabled an effective treatment of acute renal failure and excellent control on the acid–base status as well on the systemic ionised calcium in combination with negligible clotting issues.2

Intelligent software support

Ci-Ca® protocol included in the software

Supports the user with expert information and features
For routine adjustments of the Ci-Ca® therapy, information from the protocol can easily be retrieved on the screen
In case of certain values set outside the standard range, the multiFiltratePRO makes the user aware of potentially risky clinical situations
multiFiltratePRO CiCa HD screen
Screen during Ci-Ca® CVVHD application provides key information from the Ci-Ca® protocol

Dedicated hardware components for citrate anticoagulation

Clear allocation of functionality

Dedicated pumps for citrate and calcium keep the syringe pump available for heparin application if needed during Ci-Ca® therapy. Separate level detectors and drip counters enable timely detection of empty bags, preventing air being transported downstream and enabling a smooth continuation of the treatment. During bag changes (dialysate, substituate, filtrate) the citrate infusion continues for a reliable period of time. This helps to avoid early coagulation of the system

Nurse operating multiFiltratePRO device
Nurse operating multiFiltratePRO device

Therapeutic Plasma Exchange

TPE supported by multiFiltratePRO

Therapeutic plasma exchange is a well-established extracorporeal blood purification technique.

As described by Reeves et al., “the therapeutic effects of TPE could include the removal of pathological substances from the blood, such as monoclonal paraproteins and autoantibodies, as well as the replacement of deficient plasma components when plasma is used as a replacement fluid.” 5

Indications for TPE cover selected diagnoses from different specialities:5

  • Neurology
  • Hematology
  • Rheumatology
  • Nephrology

In contrast to separation via centrifugation, multiFiltratePRO separates the plasma from the blood cells via membrane plasma separation (MPS).

Therapeutic Plasma Exchange (TPE) with multiFiltratePRO
Therapeutic Plasma Exchange (TPE) with multiFiltratePRO

multiFiltratePRO TPE – Benefits at a glance

Easy set-up
Touchscreen-based interface guides the nurse through the entire setup, rinsing and priming.

Key information on the screen
Pressure display, exchanged volume and target plasma volume, treatment time, flow rates and pressure history.

Integrated automated plasma volume calculation
The patient’s plasma volume and the respective plasma exchange volume can be calculated by the plasma calculator of the multiFiltratePRO, according to Sprenger et al.6

Substitution fluid holder
Placed on the upper scale tray, the substitution fluid holder allows for easy bottle and bag handling at eye-level.

Two integrated substitution fluid heater bags
Two integrated substitution fluid heater bags gently warm the substitution solution to curtail the cooling of the patient.

Automated ramp-up of plasma separation
The multiFiltratePRO features a plasma to blood ratio ramp-up procedure to provide for a smooth start of plasma separation and stable filtration conditions7, while saving the user time, see figure 1: Plasma to blood ratio ramp-up.

multiFiltratePRO TPE
Plasma to blood ratio ramp-up
Figure 1: Plasma to blood ratio ramp-up

Convenient handling

Large and adjustable monitor

Advanced graphic user interface

multiFiltratePRO interface
multiFiltratePRO interface

The multiFiltratePRO includes a graphic user interface that monitors and displays all relevant set-up and treatment data. The integrated alarm system helps to quickly determine the urgency as well as the root cause of alarms.

The time until the next expected user action is displayed in the status bar at the top right of the screen. In addition, a list of further upcoming user interactions can be retrieved on the screen. Both help to optimize work processes in the ICU.

The “Care Button” switches the multiFiltratePRO into care-mode, by decreasing the blood flow, stopping the balancing system and extending the pressure limits. This will prevent unnecessary alarms when moving the patient or manipulating the catheter.

Easy application of CRRT

Related content


KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements 2012. 2:1-138.
2 Morgera S et al., A safe citrate anticoagulation protocol with variable treatment efficacy and excellent control of the acid-base status. Critical Care Medicine 2009. 37:2018-24.
3 Morgera S et al., Metabolic complications during regional citrate anticoagulation in continuous venovenous hemodialysis: single-center experience. Nephron Clinical Practice 2004. 97:c131-6.
4 Kalb R et al., Regional citrate anticoagulation for high volume continuous venovenous hemodialysis in surgical patients with high bleeding risk. Therapeutic Apheresis and Dialysis 2013. 17:202-12.
5 Reeves HM et al. The mechanisms of action of plasma exchange. British Journal of Haematology 2014;164(3):342-51.
Sprenger KB et al. Nomograms for the prediction of patient’s plasma volume in plasma exchange therapy from height, weight, and hematocrit. Journal of Clinical Apheresis 1987;3(3):185-90.
Malchesky PS Membrane processes for plasma separation and plasma fractionation: guiding principles for clinical use. Therapeutic Apheresis 2001;5(4):270–282.